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. 2015 Aug 18;10(8):e0134597. doi: 10.1371/journal.pone.0134597

Table 3. Costs and ranges of medications, procedures and medical tests due to medication adverse event in US dollars, 2014.

Medication a , b Base Monthly Price Low c High c
INH 1.00 0.70 1.30
RIF 26.00 18.20 33.80
PZA 35.00 24.50 45.50
EMB 20.00 14.00 26.00
AMK 176.00 123.20 228.80
MFX 80.00 56.00 104.00
PAS 173.00 121.10 224.90
CS 435.00 304.50 565.50
LNZ 1064.00 744.80 1383.20
Procedures Base Cost Low High
Acute hepatitis panel 65.47 45.83 85.11
Ankle magnetic resonance imaging (MRI) 547.77 383.44 712.10
Ankle radiograph 34.70 24.29 45.11
Arthrocentesis 45.93 32.15 59.71
Audiogram 42.88 30.02 55.74
Assay of calcium 7.09 4.96 9.22
Assay of creatinine 7.04 4.93 9.15
Assay of magnesium 9.21 6.45 11.97
Blood transfusion 34.70 24.29 45.11
Color vision examination 52.42 36.69 68.15
Comprehensive metabolic panel 14.53 10.17 18.89
Complete blood count 10.69 7.48 13.90
Electrolyte panel 9.64 6.75 12.53
Eye exam for a new patient 100.03 70.02 130.04
Hemodialysis 71.11 49.78 92.44
Hepatic function panel 11.23 7.86 14.60
Liver transplantation d 230800.00 161560.00 300040.00
Nonsteroidal anti-inflammatory drugs 10.00 7.00 13.00
Office consultation (nephrology) 107.85 75.50 140.21
Office consultation (rheumatology) 107.85 75.50 140.21
Office consultation (surgery) 107.85 75.50 140.21
Office or outpatient visit for established patient (physician) 107.85 75.50 140.21
Office or outpatient visit for established patient (nurse) 8.85 6.20 11.51
One percent hydrocortisone cream 10.00 7.00 13.00
Physical therapy evaluation 31.98 22.39 41.57
Routine ECG with at least 12 leads; with interpretation and report 18.37 12.86 23.88
TB inpatient hospital day e 1813.82 1269.67 2357.97
Therapeutic drug monitoring 619.00 433.30 804.70
Thyroid function panel 47.96 33.57 62.35
Treatment for gout with allopurinol and colchicine 20.00 14.00 26.00
Uric acid 6.21 4.35 8.07
Visual acuity screen 2.35 1.65 3.06

Sources: [10] and [31], except for Transplant, [32]

a. Medications were based on public health pricing and standard dosing: INH 300mg daily, RIF 600mg daily, PZA 25mg/kg daily, EMB 15mg/kg daily, Amikacin 15mg/kg daily, Moxifloxacin 400mg daily, PAS 6gm daily, Cycloserine 500mg daily, Linezolid 600mg daily.

b. Drug abbreviations: INH—isoniazid, RIF—rifampin, PZA—pyrazinamide, EMB—ethambutol, MFX—moxifloxacin, AMK—amikacin, CS—cycloserine, LNZ—linezolid, PAS—para-aminosalicylic acid

c. Reported ranges for costs are 30% lower and higher than the baseline costs and are the values used in simulations.

d. 40% of the billed cost of a liver transplantation as reported in the referenced source.

e. Adapted from [33]