Table 3. Costs and ranges of medications, procedures and medical tests due to medication adverse event in US dollars, 2014.
Medication a , b | Base Monthly Price | Low c | High c |
INH | 1.00 | 0.70 | 1.30 |
RIF | 26.00 | 18.20 | 33.80 |
PZA | 35.00 | 24.50 | 45.50 |
EMB | 20.00 | 14.00 | 26.00 |
AMK | 176.00 | 123.20 | 228.80 |
MFX | 80.00 | 56.00 | 104.00 |
PAS | 173.00 | 121.10 | 224.90 |
CS | 435.00 | 304.50 | 565.50 |
LNZ | 1064.00 | 744.80 | 1383.20 |
Procedures | Base Cost | Low | High |
Acute hepatitis panel | 65.47 | 45.83 | 85.11 |
Ankle magnetic resonance imaging (MRI) | 547.77 | 383.44 | 712.10 |
Ankle radiograph | 34.70 | 24.29 | 45.11 |
Arthrocentesis | 45.93 | 32.15 | 59.71 |
Audiogram | 42.88 | 30.02 | 55.74 |
Assay of calcium | 7.09 | 4.96 | 9.22 |
Assay of creatinine | 7.04 | 4.93 | 9.15 |
Assay of magnesium | 9.21 | 6.45 | 11.97 |
Blood transfusion | 34.70 | 24.29 | 45.11 |
Color vision examination | 52.42 | 36.69 | 68.15 |
Comprehensive metabolic panel | 14.53 | 10.17 | 18.89 |
Complete blood count | 10.69 | 7.48 | 13.90 |
Electrolyte panel | 9.64 | 6.75 | 12.53 |
Eye exam for a new patient | 100.03 | 70.02 | 130.04 |
Hemodialysis | 71.11 | 49.78 | 92.44 |
Hepatic function panel | 11.23 | 7.86 | 14.60 |
Liver transplantation d | 230800.00 | 161560.00 | 300040.00 |
Nonsteroidal anti-inflammatory drugs | 10.00 | 7.00 | 13.00 |
Office consultation (nephrology) | 107.85 | 75.50 | 140.21 |
Office consultation (rheumatology) | 107.85 | 75.50 | 140.21 |
Office consultation (surgery) | 107.85 | 75.50 | 140.21 |
Office or outpatient visit for established patient (physician) | 107.85 | 75.50 | 140.21 |
Office or outpatient visit for established patient (nurse) | 8.85 | 6.20 | 11.51 |
One percent hydrocortisone cream | 10.00 | 7.00 | 13.00 |
Physical therapy evaluation | 31.98 | 22.39 | 41.57 |
Routine ECG with at least 12 leads; with interpretation and report | 18.37 | 12.86 | 23.88 |
TB inpatient hospital day e | 1813.82 | 1269.67 | 2357.97 |
Therapeutic drug monitoring | 619.00 | 433.30 | 804.70 |
Thyroid function panel | 47.96 | 33.57 | 62.35 |
Treatment for gout with allopurinol and colchicine | 20.00 | 14.00 | 26.00 |
Uric acid | 6.21 | 4.35 | 8.07 |
Visual acuity screen | 2.35 | 1.65 | 3.06 |
a. Medications were based on public health pricing and standard dosing: INH 300mg daily, RIF 600mg daily, PZA 25mg/kg daily, EMB 15mg/kg daily, Amikacin 15mg/kg daily, Moxifloxacin 400mg daily, PAS 6gm daily, Cycloserine 500mg daily, Linezolid 600mg daily.
b. Drug abbreviations: INH—isoniazid, RIF—rifampin, PZA—pyrazinamide, EMB—ethambutol, MFX—moxifloxacin, AMK—amikacin, CS—cycloserine, LNZ—linezolid, PAS—para-aminosalicylic acid
c. Reported ranges for costs are 30% lower and higher than the baseline costs and are the values used in simulations.
d. 40% of the billed cost of a liver transplantation as reported in the referenced source.
e. Adapted from [33]