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. 2015 Aug 18;10(8):e0134212. doi: 10.1371/journal.pone.0134212

Fig 1. Characterization of intestinal epithelial deletion of Dclk1 under normal conditions.

Fig 1

A. There is no detectable Dclk1 in the colonic epithelia of VillinCre;Dclk1f/f mice. Colonic tissues stained with anti-Dclk1 antibody (Brown) under normal conditions (200x magnification). B. Dclk1 mRNA levels were dramatically decreased in the VillinCre;Dclk1f/f mice; C. The expression levels of Dclk1 and TJPs in Dclk1f/f and VillinCre;Dclk1f/f mice; D. Intestinal mucosal integrity was impaired in the VillinCre;Dclk1f/f mice. FITC-Dextran level in the serum of each mouse was determined 4 h after gavage (n = 3 for each group, *p<0.02).