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. 2015 Aug 18;10(8):e0135760. doi: 10.1371/journal.pone.0135760

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© 2015 Sugimori et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 5 — (A) U87-derived GS clones were developed in the absence (0 μM, black circle) and the presence of 25 (blue), 125 (orange) and 625 (red) μM of Temozolomide. Temozolomide is a GS-targeting that is thought to suppress survival, potency of self-renewal and clonal expansion of GS clones. (B)-(G) Recapitulation of power-laws in growth of the GS clones in the presence of Temozolomide. The graphs show double logarithmic plot of number of cells/ clone and of the frequency in each generation (1^st to 6^th).