Table 5. Changes in ion levels in the livers and lungs of K-ras^LA1 mice fed a normal or high-phosphate diet for 1, 2, or 4 months.

	1 month				2 months				4 months
	Liver		Lung		Liver		Lung		Liver		Lung
	ND	HPD	ND	HPD	ND	HPD	ND	HPD	ND	HPD	ND	HPD
P (μg/g)	3041.5 ± 112	3334.8 ± 84	2048.6 ± 67	2146.4 ± 59	3371.3 ± 94	3570.6 ± 97	2598.6 ± 67	2724.7 ± 41	2870.9 ± 44	3380.7 ± 58*	2229.8 ± 52	2396.2 ± 39
S (μg/g)	2620.2 ± 76	2908.5 ± 60	n/a	89.4 ± 4.8	2735.2 ± 39	3043.4 ± 89*	2.5 ± 0.08	274.4 ± 8.2**	2330.2 ±48	9222.1 ± 209**	167.6 ± 12.1	308.9 ± 11.9*
Ca (μg/g)	22.9 ± 1.89	47.1 ± 3.29**	22.5 ± 2.93	n/a	26.4 ± 2.12	58.0 ± 3.92*	33.3 ± 1.21	98.8 ± 4.98*	92.3 ± 8.21	63.5 ± 3.65*	60.8 ± 7.21	86.2 ± 5.23*
Na (μg/g)	587.9 ± 23.1	679.3 ± 41	2242.7 ± 98.2	2046.6 ± 89.5	645.7 ± 35.1	544.8 ± 29.3	4909.9 ± 213	2452.6 ± 108**	587.9 ± 29.3	722.4 ± 41.2*	2133.5 ± 93.2	2111.0 ± 49.1
Fe (pg/g)	86186.2 ± 2132	102044.0 ± 3654*	29003.6 ± 872	48475.1 ± 998**	113192.7 ± 3984	96882.5 ± 1894*	63109.7 ± 2132	52227.8 ± 1751	71967.5 ± 1620	179979.0 ± 2178**	59086.9 ± 2100	68112.9 ± 1985*
Mn (pg/g)	685.8 ± 39	554.0 ± 41	n/a	n/a	734.4± 21	614.1± 52	n/a	n/a	480.3 ± 29	665.4 ± 37*	n/a	n/a
Cu (pg/g)	6042.6± 102	7328.3 ± 97*	2695.4 ± 32	2195.7 ± 73**	6682.5 ± 92	6734.2 ± 107	43564.5 ± 325	3413.9 ± 298*	3882.9 ± 42	6586.7 ± 49**	30238.4 ± 121	39087.0 ± 872*
Zn (pg/g)	25118.7 ± 548	26758.8 ± 498	11980.6 ± 198	13108.0 ± 244*	28190.6 ± 319	27771.9 ± 299	14991.7 ± 177	17246.1 ± 142*	29098.7 ± 320	32177.9 ± 211**	29801.9 ± 176	35900.7 ± 189**

ND, normal diet; HPD, high-phosphate diet.

Ion levels were measured by inductively coupled plasma (ICP)-mass spectrometry or ICP-optical emission spectrometry.

Data are presented as mean ± SD (n = 6).

*P < 0.05

**P < 0.01

n/a, not available.