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. 2015 Aug 18;12(8):e1001865. doi: 10.1371/journal.pmed.1001865

Table 7. Results of instrumental variable analysis.

 Method * Birth Length Birth Weight Gestational Age
beta se p-value beta se p-value Beta se p-value
Method 1 0.0692 0.0161 1.64E-05 13.4 2.53 1.21E-07 0.280 0.135 0.0385
Method 2 0.0298 0.0214 0.164 5.70 3.30 0.0837 0.387 0.176 0.0276
Method 3 0.0501 0.0236 0.0336 2.47 3.70 0.504 0.440 0.194 0.0234
Method 4 0.0418 0.0257 0.104 0.486 3.96 0.170 0.475 0.209 0.0232

* Method 1 and method 2 use maternal genotype-based genetic score (M) as the instrument variable for maternal height without (method 1) or with (method 2) controlling for fetal genetic score (C). Method 3 utilizes maternal nontransmitted haplotype score (M2) as a valid instrument for maternal height. Method 4 uses maternal nontransmitted haplotype score (M2) as the instrument variable and further adjusts for possible bias due to assortative mating by controlling for maternal and paternal transmitted scores (M1/C1 and C2) as covariates.