Table 7. Results of instrumental variable analysis.
Method * | Birth Length | Birth Weight | Gestational Age | ||||||
---|---|---|---|---|---|---|---|---|---|
beta | se | p-value | beta | se | p-value | Beta | se | p-value | |
Method 1 | 0.0692 | 0.0161 | 1.64E-05 | 13.4 | 2.53 | 1.21E-07 | 0.280 | 0.135 | 0.0385 |
Method 2 | 0.0298 | 0.0214 | 0.164 | 5.70 | 3.30 | 0.0837 | 0.387 | 0.176 | 0.0276 |
Method 3 | 0.0501 | 0.0236 | 0.0336 | 2.47 | 3.70 | 0.504 | 0.440 | 0.194 | 0.0234 |
Method 4 | 0.0418 | 0.0257 | 0.104 | 0.486 | 3.96 | 0.170 | 0.475 | 0.209 | 0.0232 |
* Method 1 and method 2 use maternal genotype-based genetic score (M) as the instrument variable for maternal height without (method 1) or with (method 2) controlling for fetal genetic score (C). Method 3 utilizes maternal nontransmitted haplotype score (M2) as a valid instrument for maternal height. Method 4 uses maternal nontransmitted haplotype score (M2) as the instrument variable and further adjusts for possible bias due to assortative mating by controlling for maternal and paternal transmitted scores (M1/C1 and C2) as covariates.