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. Author manuscript; available in PMC: 2015 Aug 18.
Published in final edited form as: J Neurochem. 2011 Jan 24;116(6):1066–1076. doi: 10.1111/j.1471-4159.2010.07161.x

Table 1.

Multiple Pet-1 elements in serotonergic genes

Gene Site Sequence
h5-HTT −1154/1144 GATAGGAAGTA
h5-HTT −1172/1162 GAAAGGAAATA
m5-HTT −2424/2414 CCCAGGAAATG
m5-HTT −2024/2014 GGGAGGAAATG
hTPH1 −1154/1144 ATACGGAAATT
mTPH1 −790/780 TACAGGATATA
h-AADC Intron TTCAGGAAATT
h5-HT1A −136/126 R AGCAGGAAGTT
h5-HT1A −111/101 R CGGAGGAAGGG
h5-HT1A −449/439 F GGAAGGAAATA
h5-HT1A −532/522 F GAAGGGAAAGT
h5-HT1A −931/921 R AAAAGGAAGCA
h5-HT1A −1406/1396 R GGATGGAAATA
PEA3 TCCAGGAAGTG
Consensus RRMAGGAARTR

Alignment of consensus Pet-1 elements previously identified (Hendricks et al. 1999), as well as putative additional elements in the 5-HT1A promoter identified using the Transcription Element Search Software (TESS) (Schug 2008), including their respective positions with respect to the start ATG and presence on the coding (F) or non-coding (R) strand. 5-HTT, serotonin transporter; AADC, amino acid decarboxylase; TPH1, tryptophan hydroxylase-1; PEA3, polyomavirus enhancer activator 3. R=G or A, M=A or C. Highlighted is the position of the minimal GGAA Pet-1 binding core.