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Synergistic repression of C. difficile toxin synthesis by CodY and CcpA. Responding independently to different nutritional signals, CcpA and CodY both bind to the regulatory region of the tcdR gene, repressing production of the alternative sigma factor necessary for high-level toxin gene (tcdA and tcdB) expression. doi:10.1128/microbiolspec.MBP-0004 -2014.f2
