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. Author manuscript; available in PMC: 2015 Oct 7.
Published in final edited form as: Chem Soc Rev. 2015 Jun 9;44(17):6258–6286. doi: 10.1039/c4cs00511b

Figure 4.

Figure 4

Re-education of the primary tumour microenvironment (TME) with nanomedicines to block the initiation of metastasis. Nanomedicines can be engineered to co-load multiple drugs with different functions and co-deliver them to tumour for synergetic re-education of the TME containing cancer cells, stromal cells and their exosomes by various routes including anti-angiogenesis, anti-lymphangiogenesis, repolarization of TAMs and immunomodulation.