Figure 2.
Oral administration of D156844 augmented the follistatin-induced increase in the onset of loss in body mass of SMNΔ7 SMA mice. Kaplan-Meier onset of body mass loss plot for SMNΔ7 SMA mice receiving either vehicle (light gray dotted line; n = 17), 1 mg/kg/qad follistatin (gray dashed line; n = 20) or a combination of 3 mg/kg/d D156844 and 1 mg/kg/qad follistatin (solid line; n = 23). Treatment of SMNΔ7 SMA mice began at PND04.