Fig. 2.

Spatial and tissue distribution of intravenous and IP injections of ³H-paclitaxel solubilized in Cremophor micelles. A mouse was given an IP or intravenous injection of the Cremophor formulation of paclitaxel (a mixture of radiolabeled and nonlabeled paclitaxel, equivalent to 10 mg/kg and 1 mCi/kg). a Whole body section of a mouse. b Densitometric signals of microscale tritium standards. The numbers correspond to the relative concentrations, with the highest level set at 100%. c Whole body autoradiographs at various time points after an intravenous dose. d Whole body autoradiographs after an IP dose. e Relative tissue concentration-time profiles, determined by digital videodensitometry, after an intravenous dose (open symbols, dotted lines) or an IP dose (closed symbols, solid lines). Reprinted from (7) with permission