Fig. 8.
Comparison of experimentally-observed and model-simulated spatiokinetics in tumors. Mice bearing implanted IP SKOV3 tumors were treated with a mixture of 3H-paclitaxel and nonradiolabeled paclitaxel. At 6 h post-treatment, tumors were excised and processed for autoradiography. Drug concentrations were obtained by converting the grayscale values derived from densitometric analysis of autoradiograms. Results were normalized to a paclitaxel-equivalent dose of 10 mg/kg. a Autoradiograms of four tumors (one per mouse). b Concentration-tumor depth profile at 6 h. Solid line: model-simulated profile. Symbols and bars: mean (±1 SD). Inset: model-simulated (solid line) vs. profiles of individual tumors (symbols). Reprinted with permission (3)