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Predicted Mean PK Parameters of Losartan from Population Simulations of Three Tablet Formulations, Under Fasted Condition at 50 mg Dose
| AUC0–24 h
(μg×hr/mL) |
C
max
(μg/mL) |
Relative AUC0–24h |
Relative C max |
|
|---|---|---|---|---|
| “Target” tablet | 0.681 | 0.183 | – | – |
| “Slow” tablet | 0.681 | 0.186 | 1.00 | 1.02 |
| “Fast” tablet | 0.682 | 0.185 | 1.00 | 1.01 |
AUC area under the curve
