Table IV.
Effect of EPO and Anakinra on Inflammatory Genes in the Livers of TBI Animals
| Affymetrix ID | Gene symbol | Genes | a | a |
|---|---|---|---|---|
| 24 h post-TBI | ||||
| 10858408 | A2m | Alpha-2-macroglobulin | 2.27 | n.s. |
| 10744425 | Alox15 | Arachidonate 15-lipoxygenase | 2.86 | n.s. |
| 10894525 | Cry1 | Cryptochrome 1 (photolyase-like) | 1.54 | n.s. |
| 10711575 | Dmbt1 | Deleted in malignant brain tumors 1 | 1.55 | n.s. |
| 10732652 | Dusp1 | Dual specificity phosphatase 1 | 1.80 | n.s. |
| 10800919 | Egr1 | Early growth response 1 | 2.09 | n.s. |
| 10878112 | Jun | Jun oncogene | 2.13 | n.s. |
| 10742402 | Ltc4s | Leukotriene C4 synthase | 1.57 | n.s. |
| 10907913 | Mmp8 | Matrix metallopeptidase 8 | 1.67 | n.s. |
| 10747813 | Slc4a1 | Solute carrier family 4 (anion exchanger), member 1 | 1.93 | n.s. |
| 10857314 | Slc6a6 | Solute carrier family 6 (neurotransmitter transporter, taurine), member 6 | 1.83 | n.s. |
| 72 h post-TBI | ||||
| 10745670 | Ccl6 | Chemokine (C-C motif) ligand 6 | 1.65 | n.s. |
| 10940473 | Cd36 | CD36 molecule | 2.97 | n.s. |
| 10777232 | Cd38 | CD38 molecule | 1.61 | n.s. |
| 10767388 | Cd55 | CD55 molecule | 1.78 | n.s. |
| 10858626 | Cd163 | CD163 molecule | 1.81 | n.s. |
| 10803110 | Cd226 | CD226 molecule | 1.59 | n.s. |
| 10765625 | Cd244 | CD244 molecule | 1.67 | n.s. |
| 10764069 | Chi3l1 | Chitinase 3-like 1 | 1.75 | n.s. |
| 10897428 | Csf2rb | Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 1.60 | n.s. |
| 10763808 | Ctse | Cathepsin E | 1.83 | n.s. |
| 10924245 | Cxcr2 | Cxcr2 | 1.79 | n.s. |
| 10936899 | Cybb | Cytochrome b-245, beta polypeptide | 1.66 | n.s. |
| 10711575 | Dmbt1 | Deleted in malignant brain tumors 1 | 1.59 | n.s. |
| 10820586 | F2r | Coagulation factor II (thrombin) receptor | 1.57 | n.s. |
| 10812589 | F2rl2 | Coagulation factor II (thrombin) receptor-like 2 | 2.49 | n.s. |
| 10794734 | F13a1 | Coagulation factor XIII, A1 polypeptide | 1.72 | n.s. |
| 10813392 | Fyb | FYN binding protein (FYB-120/130) | 1.63 | n.s. |
| 10797527 | Gadd45g | Growth arrest and DNA-damage-inducible, gamma | n.s. | 1.67 |
| 10735317 | Gp1ba | Glycoprotein Ib (platelet), alpha polypeptide | 1.62 | n.s. |
| 10897805 | Grap2 | GRB2-related adaptor protein 2 | 2.38 | n.s. |
| 10923036 | Gulp1 | GULP, engulfment adaptor PTB domain containing 1 | 1.53 | n.s. |
| 10821370 | Gzma | Granzyme A | 1.61 | n.s. |
| 10860351 | Hgf | Hepatocyte growth factor | 1.60 | n.s. |
| 10806122 | Hmox1 | Heme oxygenase (decycling) 1 | 1.95 | n.s. |
| 10862842 | Hpgds | Hematopoietic prostaglandin D synthase | 1.78 | n.s. |
| 10729791 | Ifit1 | Interferon-induced protein with tetratricopeptide repeats 1 | 8.60 | n.s. |
| 10774141 | Igfbp1 | Insulin-like growth factor binding protein 1 | 2.08 | 1.92 |
| 10708015 | Isg20 | Interferon stimulated exonuclease gene 20 | 1.80 | n.s. |
| 10821851 | Il7r | Interleukin 7 receptor | 2.24 | n.s. |
| 10909874 | Il18 | Interleukin 18 | 1.55 | n.s. |
| 10832306 | Itgb2 | Integrin, beta 2 | 1.62 | n.s. |
| 10806585 | Junb | Jun B proto-oncogene | 1.75 | n.s. |
| 10844331 | Lcn2 | Lipocalin 2 | 3.51 | n.s. |
| 10779673 | Lgals3 | Lectin, galactoside-binding, soluble, 3 | 1.87 | n.s. |
| 10902547 | Lyz2 | Lysozyme 2 | 1.69 | n.s. |
| 10930693 | Marco | Macrophage receptor with collagenous structure | 1.63 | n.s. |
| 10907913 | Mmp8 | Matrix metallopeptidase 8 | 4.99 | n.s. |
| 10796476 | Mrc1 | Mannose receptor, C type 1 | 1.52 | n.s. |
| 10855506 | Npy | Neuropeptide Y | 2.20 | n.s. |
| 10775914 | Pf4 | Platelet factor 4 | 1.54 | n.s. |
| 10873341 | Pla2g2a | Phospholipase A2, group IIA (platelets, synovial fluid) | 1.60 | n.s. |
| 10768376 | Pla2g4a | Phospholipase A2, group IVA (cytosolic, calcium-dependent) | 1.63 | n.s. |
| 10771406 | Plac8 | Placenta-specific 8 | 1.86 | n.s. |
| 10778558 | Plek | Pleckstrin | 2.06 | n.s. |
| 10775918 | Ppbp | Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 3.56 | n.s. |
| 10810018 | Prdx2 | Peroxiredoxin 2 | 2.00 | n.s. |
| 10837381 | Prg2 | Proteoglycan 2, bone marrow | 1.72 | n.s. |
| 10768138 | Ptprc | Protein tyrosine phosphatase, receptor type, C | 1.63 | n.s. |
| 10742194 | Pttg1 | Pituitary tumor-transforming 1 | 1.75 | n.s. |
| 10817071 | S100a8 | S100 calcium binding protein A8 | 1.77 | n.s. |
| 10824695 | S100a9 | S100 calcium binding protein A9 | 2.78 | n.s. |
| 10752744 | Samsn1 | SAM domain, SH3 domain and nuclear localization signals, 1 | 1.64 | n.s. |
| 10765186 | Sell | Selectin L | 1.90 | n.s. |
| 10759173 | Selplg | Selectin P ligand | 1.51 | n.s. |
| 10763367 | Serpinb2 | Serpin peptidase inhibitor, clade B (ovalbumin),member 2 | 1.83 | n.s. |
| 10747813 | Slc4a1 | Solute carrier family 4 (anion exchanger), member 1 | 6.09 | n.s. |
| 10862820 | Snca | Synuclein, alpha (non A4 component of amyloid precursor) | 2.87 | n.s. |
| 10901996 | Socs2 | Suppressor of cytokine signaling 2 | n.s. | 0.37 |
| 10833180 | Srgn | Serglycin | 1.65 | n.s. |
| 10856525 | Tacr1 | Tachykinin receptor 1 | 2.41 | n.s. |
| 10746976 | Top2a | Topoisomerase (DNA) II alpha | 1.91 | n.s. |
| 10709093 | Ucp2 | Uncoupling protein 2 (mitochondrial, proton carrier) | 2.65 | n.s. |
| 7 days post-TBI | ||||
| 10901166 | Angptl4 | Angiopoietin-like 4 | n.s. | 0.55 |
| 10751931 | Bcl6 | B cell CLL/lymphoma 6 | n.s. | 2.30 |
| 10727260 | Ccnd1 | Cyclin D1 | 0.59 | n.s. |
| 10940473 | Cd36 | CD36 molecule (thrombospondin receptor) | 1.98 | n.s. |
| 10828827 | Cdkn1a | Cyclin-dependent kinase inhibitor 1A | 0.62 | n.s. |
| 10732652 | Dusp1 | Dual specificity phosphatase 1 | n.s. | 0.54 |
| 10769825 | Fcer1g | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | n.s. | 0.65 |
| 10729791 | Ifit1 | Interferon-induced protein with tetratricopeptide repeats 1 | 9.90 | n.s. |
| 10804463 | Lox | Lysyl oxidase | 0.43 | n.s. |
| 10855506 | Npy | Neuropeptide Y | n.s. | 0.59 |
| 10775914 | Pf4 | Platelet factor 4 | 1.50 | n.s. |
| 10775918 | Ppbp | Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 1.81 | n.s. |
| 10901996 | Socs2 | Suppressor of cytokine signaling 2 | n.s. | 0.25 |
| 10709093 | Ucp2 | Uncoupling protein 2 (mitochondrial, proton carrier) | 2.46 | n.s. |
aFold change in gene expression
n.s. not significant