TABLE VI.

Effect of Erythropoietin and Anakinra on Hepatic Metabolizing Enzymes in TBI Animals. Genes Differentially Expressed (>1.5-fold change, p < 0.05)

Affymetrix ID	Gene symbol	Genes	$\frac{\mathrm{E}\mathrm{P}\mathrm{O}+\mathrm{T}\mathrm{B}\mathrm{I}}{\mathrm{Vehicle}+\mathrm{T}\mathrm{B}\mathrm{I}}$ a	$\frac{\mathrm{Anakinra}+\mathrm{T}\mathrm{B}\mathrm{I}}{\mathrm{Vehicle}+\mathrm{T}\mathrm{B}\mathrm{I}}$ a
24 h post-TBI
10875324	Cyp7a1	Cytochrome P450, family 7, subfamily a, polypeptide 1	n.s.	1.93
10863686	Nat8	N-Acetyltransferase 8	1.87	1.51
72 h post-TBI
10905721	Cyp2d4	Cytochrome P450, family 2, subfamily d, polypeptide 4	0.65	n.s.
10914411	Cyp8b1	Cytochrome P450, family 8, subfamily b, polypeptide 1	0.62	n.s.
10719187	Sult2a1	Sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	n.s.	0.66
7 days post-TBI
10930766	Cyp2c12	Cytochrome P450, family 2, subfamily c, polypeptide 12	n.s.	1.51
10875324	Cyp7a1	Cytochrome P450, family 7, subfamily a, polypeptide 1	2.11	2.55
10730599	Cyp17a1	Cytochrome P450, family 17, subfamily a, polypeptide 1	0.40	n.s.
10769385	Fmo3	Flavin containing monooxygenase 3	0.61	n.s.
10855008	Gstk1	Glutathione S-transferase kappa 1	n.s.	0.66
10771936	Ugt2a3	UDP glucuronosyltransferase 2 family, polypeptide A3	0.63	n.s.

^aFold change in gene expression

n.s. not significant