Table III.

Regional P _eff,int Values (Open Perfusion System) and Prediction of the Ileal Absorption Clearance Estimated by Three Different Methods

Compound	BCS classa	P eff,int (jejunum) b (×10−4 cm/s)			P eff,int (ileum) b (×10−4 cm/s)			Observedc ileal CLabs (×10−4 cm3/s)	Predictedd ileal CL abs (×10−4 cm3/s)
		M1	M2	M3	M1	M2	M3		M1	M2	M3
Hydrocortisone	2	8.79	0.032	0.046	5.57	0.027	0.050	787	1242	928	724
Triamcinolone acetonide	2	4.16	0.015	0.022	9.94	0.049	0.090	1405	588	439	343
Paracetamol	1	4.79	0.018	0.025	7.17	0.036	0.065	2028	1356	1012	790
Salicylic acid	1	2.67	0.011	0.014	4.12	0.024	0.037	3108	2010	1500	1171
Hydrochlorothiazide	4	0.18	0.00079	0.0010	0.16	0.00089	0.0014	117	139	104	81
Atenonol	3	0.38	0.0016	0.0020	0.27	0.0016	0.0025	206	283	211	165
Furosemide	4	0.48	0.0021	0.0025	0.22	0.0013	0.0020	166	365	272	213
Cimetidine	3	0.77	0.0033	0.0040	0.30	0.0017	0.0027	228	580	433	338
Talinonol	4	0.31	0.0012	0.0016	0.37	0.0019	0.0034	106	88	66	52
Griseofulvine	2	7.47	0.028	0.039	11.57	0.057	0.10	2181	1407	1051	820
Ranitidine	3	1.74	0.0066	0.0091	1.41	0.0072	0.013	400	492	367	287

^aBCS classification extracted from references (4,5)

^bOpen perfusion regional permeability values were re-calculated from references (4,5,44–49) and the mSA values shown in Table I

^cObserved regional absorption clearances were re-calculated from references (4,5,44–49) employing a parallel tube model (Eq. 7); the details for the calculations can be found in the Section 2 of the Supplementary Material

^dPredicted values from Eq. 8, using jejunal P _eff data derived by the open perfusion system and ileal mSA data from Table I