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Docking results of bitopic ligand-SB269652 at dopamine 2 receptor (D2R). a The binding mode of the orthosteric fragment 1,2,3,4-tetrahydroisoquinoline-7-carbonitrile (THIQ7C) at the orthosteric binding site, b the binding mode of the allosteric fragment at the allosteric binding site (TM1-2-7 region), c the binding mode of the whole structure of SB269652
