Fig. 2.

Preclinical and clinical performance of Sebashell AuNPs currently undergoing clinical trials. a NIR light absorption of Sebashells produces heat. b Schematic illustrating the topical application of Sebashells, ultrasound-mediated penetration of Sebashells, and NIR-laser-induced ablation of sebaceous glands using Sebashells. c Two-photon-induced photoluminescence imaging shows the localization of Sebashells in a sebaceous gland in porcine skin in vitro. d Deep glandular thermolysis following NIR-induced ablation of sebaceous gland localized Sebashells. e Clinical data in humans showing thermolysis as a function of ultrasound exposure. a–e Adapted from (39), copyright (2015), with permission from Elsevier