Table I.
List of Clinical Trials for inorganic nanoparticles which are currently active or recruiting (retrieved from www.clinicaltrials.gov)
| Name | Material/functionality | Application/indication | ClinicalTrials.gov identifier |
|---|---|---|---|
| Feraheme®; Rienso®; Ferumoxytol | Iron oxide nanoparticles (coated with polyglucose sorbitol carboxymethylether). Magnetic-field responsive nanoparticles for MRI imaging. Investigated in many clinical trials in combination with various targeting agents and other imaging agents. | Imaging: Multiple sclerosis and demyelinating diseases. Bone sarcomas and osteomyelitis. Triple negative breast, non small cell lung, colorectal, pancreatic, ovarian, gastric, head and neck, lymph node, prostate, bladder, kidney, and thyroid cancers. Neuroinflammation in epilepsy. Type 1 diabetes progression. Peripheral arterial disease. Heart inflammation. Myocardial infarction. Carotid atherosclerosis. Whole body imaging for cancer staging. Kidney transplant rejection | Imaging: NCT00978562, NCT00103038, NCT01973517, NCT01336803, NCT01770353, NCT00659126, NCT02084303, NCT01895829, NCT01815333, NCT01521520, NCT02189889, NCT02141490, NCT01927887, NCT02253602, NCT00707876, NCT02319278, NCT01995799, NCT01674257, NCT01542879, NCT02359097, and NCT02006108 |
| Anemia: Pediatric patients with chronic kidney disease. Peritoneal dialysis patients. Preoperative management in patients undergoing cardiac surgery | Anemia: NCT01264679, NCT01942460, and NCT02189889 | ||
| Ferumoxtran-10; Combidex®; Sineren® | Iron oxide nanoparticles (coated with dextran). Magnetic-field responsive for MRI imaging | Lymph node imaging | NCT00416455 |
| AuroLase® | Silica-gold nanoshells coated with PEG. Laser responsive | Thermal ablation of solid tumors: Head/neck cancer. Primary and/or metastatic lung tumors | NCT00848042; NCT01679470 |
| Cornell Dots | Silica nanoparticles with a NIR fluorophore, PEG coating, and a 124I radiolabeled cRGDY targeting peptide. PET and flourescent imaging | Imaging: Melanoma and malignant brain tumors. Intraoperative sentinel lymph node mapping | NCT01266096; NCT02106598 |
| NBTXR3 | Crystalized hafnium oxide nanoparticles. X-ray responsive | Enhanced radiotherapy for tumor treatment | NCT01433068; NCT01946867 |
| Sebacia Microparticles | Gold particles with silica core. Laser responsive | Treatment of moderate to moderately severe inflammatory acne vulgaris | NCT02219074; NCT02217228 |
| Sienna+® | Iron oxide particles (coated with carboxydextran). Magnetic responsive particles use with SentiMag® device | Mark and locate cancerous lymph nodes prior to surgery | NCT01790399; NCT02249208 |
| Silver | Nanosilver flouride. Silver nanoparticles added to fluor varnish | Prevent dental biofilm growth. Dental remineralization | NCT01950546; NCT01975545 |
| Magnablate | Iron nanoparticles. Magnetic-field responsive for thermal ablation | Prostate cancer | NCT02033447 |
| Sensors functionalized with gold nanoparticles | Organic functionalized gold nanoparticles | Detection of gastric lesions | NCT01420588 |
| Buckypaper | Macroscopic aggregate of carbon nanotubes | Fixing method for treatment of abdominal wall hernias | NCT02328352 |