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. 2015 Aug 19;35(33):11514–11531. doi: 10.1523/JNEUROSCI.5288-14.2015

Figure 6.

Figure 6.

Age-dependent impairment of neuromuscular synaptic transmission in UbG76V-GFP-Syb2 mice. A, B, Sample traces of mEPPs (A) and EPPs (B) from control and UbG76V-GFP-Syb2 mice (1 and 8 months of age). C, D, Quantification of mEPP frequency (C) and amplitude (D) in control and UbG76V-GFP-Syb2 mice at 1, 3, 5, 8, and 10 months of age. After 3 months of age, mEPP frequency is significantly decreased in UbG76V-GFP-Syb2 mice compared with age-matched controls. p = 0.0218 (3 months of age); p = 0.0144 (5 months of age); p = 0.0382 (8 months of age); p = 0.0035 (10 months of age). In contrast, mEPP amplitudes remained similar between control and UbG76V-GFP-Syb2 mice. E, F, Quantification of EPP amplitudes (E) and quantal content (F). After 5 months of age, EPP amplitudes are significantly reduced in UbG76V-GFP-Syb2 mice, compared with controls. p = 0.0156 (5 months of age); p = 0.0055 (8 months of age); p = 0.0049 (10 months of age). F, Quantal content is also significantly decreased at 5, 8, and 10 months of age in UbG76V-GFP-Syb2 mice compared with controls. p = 0.0413 (5 months of age); p = 0.0135 (8 months of age); p = 0.0030 (10 months of age). The number of muscle fibers and mice analyzed: control (n = 44 muscle fibers, N = 4 mice); and UbG76V-GFP-Syb2 mice (n = 28 muscle fibers, N = 3 mice).