Table 2.
N-back task fMRI results
| Region | Peak T | Peak MNI coordinate | Cluster volume (mm3) | Cluster p |
|---|---|---|---|---|
| Deactivations versus 0b* | ||||
| 1b | ||||
| Controls > patients: no significant clusters | ||||
| Patients > controls: no significant clusters | ||||
| 2b | ||||
| Controls > patients | ||||
| PCC/precuneus | 4.6 | −2, −69, 37 | 6646 | <0.001 |
| MPFC | 3.8 | −2, 57, −5 | 3601 | 0.012 |
| Patients > controls: no significant clusters | ||||
| 3b | ||||
| Controls > patients | ||||
| PCC/precuneus | 5.5 | 2, −62, 37 | 5016 | <0.001 |
| Activations versus 0b | ||||
| 1b | ||||
| Controls > patients: no significant clusters | ||||
| Patients > controls: no significant clusters | ||||
| 2b | ||||
| Controls > patients: no significant clusters | ||||
| Patients > controls: no significant clusters | ||||
| 3b | ||||
| Controls > patients | ||||
| VLPFC | 4.3 | −47, 26, 16 | 2830 | 0.042 |
| Fusiform gyrus† | 6.2 | −40, −55, −19 | 3516 | 0.013 |
| Patients > controls: no significant clusters |
*0b, Control condition with minimal cognitive load.
†Activation in the fusiform gyrus was correlated inversely with the amount of pain patients experienced during the scan (ρ = −0.498, p = 0.008). No other activations or deactivations were related to current pain in patients [VLPFC (3b), ρ = 0.196, p = 0.595; PCC (3b), ρ = −0.196, p = 0.318; PCC (2b), ρ = 0.071, p = 0.721; MPFC (2b), ρ = 0.156, p = 0.427].