Figure 6.

Oscillations in the dentate LFP are reduced during active behaviors in X-irradiated mice (Sham: n = 4, X-ray: n = 6). A, Average speed and (B) place avoidance behavior measured across trials shows locomotion and place avoidance of the initial shock zone were indistinguishable between the groups, but X-irradiated mice avoided less than sham-irradiated mice on the conflict trials. C, Spectrograms from a pair of representative mice during unreinforced behaviors, pretraining and the stationary arena session 1 week after place avoidance training. D, Average power spectra comparing the sham- and X-irradiated groups. The spectra during training are averaged across the three trials on that day. E, Comparison of average power in the θ (6–10 Hz) and γ (30–100 Hz) bands as a function of training. F, A Nissl-stained section through dorsal hippocampus of a sham-irradiated mouse showing the recording electrode site. A 1 s LFP trace is shown, originating at the recording site.