TABLE 2.
Results of in vitro antifungal susceptibility testing of the 92 clinical isolates included in the study
| Genus | Species (no. of isolates tested) | MIC/MEC parametera | Result (μg/ml) forb: |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AMB | 5FC | VRC | PSC | ITC | TBF | CFGc | AFGc | MFGc | |||
| Cladosporium | C. cladosporioides complex (57) | Range | 0.06–2 | 0.06–>32 | 0.25–16 | <0.03–1 | <0.03–2 | <0.03–4 | 0.125–8 | 0.03–0.5 | 0.03–0.5 |
| GM | 0.73 | 1.20 | 1.65 | 0.40 | 0.34 | 0.12 | 2.78 | 0.19 | 0.11 | ||
| MIC90 | 1 | 4 | 4 | 0.5 | 0.5 | 1 | 8 | 0.5 | 0.25 | ||
| C. tenuissimum (9) | Range | 0.5–1 | 1–>16 | 1–4 | 0.25–0.5 | 0.25–0.5 | 0.06–1 | 4–8 | 0.125–0.5 | 0.125–0.25 | |
| GM | 0.93 | 2.72 | 1.85 | 0.37 | 0.29 | 0.18 | 4.67 | 0.37 | 0.15 | ||
| MIC90 | 1.00 | 4.00 | 2.00 | 0.50 | 0.50 | 0.25 | 8.00 | 0.50 | 0.25 | ||
| C. subuliforme (5) | Range | 1–2 | 0.25–2 | 0.25–2 | 0.25–0.5 | 0.25 | 0.06–1 | 4–8 | 0.06–0.5 | 0.06–0.25 | |
| GM | 1.15 | 1.00 | 0.66 | 0.29 | 0.25 | 0.28 | 5.28 | 0.16 | 0.12 | ||
| MIC90 | 1.00 | 2.00 | 1.00 | 0.25 | 0.25 | 1.00 | 8.00 | 0.25 | 0.13 | ||
| C. pseudocladosporioides (4) | Range | 0.5–1 | 0.5–1 | 2–4 | 0.25–0.5 | 0.5–1 | 0.03–2 | 0.25–8 | 0.03–0.25 | 0.03–0.125 | |
| GM | 0.59 | 0.71 | 2.38 | 0.42 | 0.59 | 0.21 | 2.38 | 0.15 | 0.07 | ||
| MIC90 | |||||||||||
| C. cladosporioides (3) | Range | 0.5–1 | 1–2 | 0.5–16 | 0.25–1 | 0.25–0.5 | 0.5–2 | 1–4 | 0.125–0.25 | 0.125 | |
| GM | 0.79 | 1.26 | 1.59 | 0.40 | 0.31 | 1.00 | 2.00 | 0.16 | 0.13 | ||
| MIC90 | |||||||||||
| C. funiculosum (3) | Range | 0.06–1 | 0.5–1 | 0.5–2 | 0.25–0.5 | 0.125–0.25 | 0.03–0.06 | 4 | 0.06–0.25 | 0.06–0.125 | |
| GM | 0.31 | 0.63 | 1.00 | 0.31 | 0.20 | 0.04 | 4.00 | 0.12 | 0.08 | ||
| MIC90 | |||||||||||
| C. angustisporum (1) | Range | 1.00 | 1.00 | 4.00 | 0.50 | 0.50 | 2.00 | 4.00 | 0.13 | 0.06 | |
| GM | |||||||||||
| MIC90 | |||||||||||
| C. asperulatum (1) | Range | 1 | 0.25 | 2 | 0.25 | 0.5 | 0.03 | 8 | 0.25 | 0.125 | |
| GM | |||||||||||
| MIC90 | |||||||||||
| C. flabelliforme (1) | Range | 2 | 2 | 2 | 0.5 | 0.25 | 0.03 | 4 | 0.25 | 0.125 | |
| GM | |||||||||||
| MIC90 | |||||||||||
| C. perangustum (1) | Range | 0.5 | 4 | 4 | 0.5 | 0.5 | 0.03 | 4 | 0.125 | 0.06 | |
| GM | |||||||||||
| MIC90 | |||||||||||
| Cladosporium sp. (29) | Range | 0.125–2 | 0.06–>16 | 0.25–8 | <0.03–1 | <0.03–2 | <0.03–4 | 0.125–8 | 0.03–0.5 | 0.03–0.5 | |
| GM | 0.67 | 1.10 | 1.73 | 0.43 | 0.36 | 0.09 | 2.00 | 0.18 | 0.10 | ||
| MIC90 | 1.00 | 4.00 | 4.00 | 0.50 | 0.50 | 1.00 | 8.00 | 0.50 | 0.25 | ||
| C. herbarum complex (14) | Range | <0.03–2 | 0.5–>16 | 0.5–8 | 0.06–0.5 | 0.06–1 | <0.03–0.125 | 0.125–8 | 0.06–1 | 0.06–0.5 | |
| GM | 0.18 | 2.97 | 1.81 | 0.37 | 0.35 | 0.05 | 0.67 | 0.23 | 0.15 | ||
| MIC90 | 1 | 8 | 4 | 0.5 | 0.5 | 0.125 | 2 | 0.5 | 0.5 | ||
| C. allicinum (3) | Range | <0.03–0.125 | 2–4 | 2–4 | 0.5 | 0.25–0.5 | 0.03–0.06 | 1.00 | 0.25–0.5 | 0.125–0.25 | |
| GM | 0.05 | 2.52 | 3.17 | 0.50 | 0.40 | 0.05 | 1.00 | 0.31 | 0.20 | ||
| MIC90 | |||||||||||
| C. ramotenellum (3) | Range | 1–2 | 4–>16 | 1–2 | 0.5 | 0.5–1 | <0.03–0.125 | 0.5–8 | 0.25–1 | 0.125–0.5 | |
| GM | 1.26 | 4.00 | 1.59 | 0.50 | 0.63 | 0.05 | 2.00 | 0.40 | 0.20 | ||
| MIC90 | |||||||||||
| C. herbarum (1) | Range | 0.06 | 8 | 2 | 0.5 | 0.5 | 0.03 | 0.5 | 0.125 | 0.125 | |
| GM | |||||||||||
| MIC90 | |||||||||||
| C. macrocarpum (1) | Range | 0.5 | 2 | 1 | 0.25 | 0.5 | 0.125 | 1 | 0.125 | 0.5 | |
| GM | |||||||||||
| MIC90 | |||||||||||
| C. subinflatum (1) | Range | 0.5 | 0.5 | 4 | 0.5 | 0.5 | 0.03 | 0.5 | 0.5 | 0.25 | |
| GM | |||||||||||
| MIC90 | |||||||||||
| Cladosporium sp. (5) | Range | 0.06–0.5 | 2–4 | 0.5–8 | 0.06–0.5 | 0.06–0.5 | <0.03–0.125 | 0.125–0.5 | 0.06–0.5 | 0.06–0.125 | |
| GM | 0.11 | 2.30 | 1.32 | 0.25 | 0.19 | 0.05 | 0.29 | 0.14 | 0.08 | ||
| MIC90 | 1.00 | 4.00 | 4.00 | 0.50 | 0.50 | 1.00 | 8.00 | 0.50 | 0.25 | ||
| C. sphaerospermum complex (17) | Range | 0.125–2 | 0.06–4 | 0.5–16 | 0.06–4 | 0.25–>16 | <0.03–1 | 0.06–4 | <0.03–1 | 0.06–1 | |
| GM | 1.13 | 1.13 | 1.70 | 0.64 | 1.13 | 0.06 | 1.27 | 0.15 | 0.13 | ||
| MIC90 | 2 | 2 | 8 | 2 | 32 | 0.5 | 4 | 0.25 | 0.125 | ||
| C. halotolerans (13) | Range | 0.125–2 | 0.06–4 | 0.5–2 | 0.06–1 | 0.25–2 | <0.03–1 | 0.06–4 | <0.03–0.25 | 0.06–0.125 | |
| GM | 1.00 | 0.90 | 1.11 | 0.47 | 0.56 | 0.08 | 1.00 | 0.11 | 0.10 | ||
| MIC90 | 2.00 | 2.00 | 2.00 | 1.00 | 2.00 | 1.00 | 4.00 | 0.25 | 0.13 | ||
| C. sphaerospermum (3) | Range | 1–2 | 2–4 | 8–16 | 2–4 | >16 | <0.03–0.125 | 2–4 | 0.25–1 | 0.125–1 | |
| GM | 1.59 | 2.52 | 10.08 | 2.52 | >16 | 0.03 | 3.17 | 0.50 | 0.40 | ||
| MIC90 | |||||||||||
| Cladosporium sp. (1) | Range | 2 | 2 | 2 | 0.5 | 0.5 | <0.03 | 2 | 0.25 | 0.125 | |
| GM | |||||||||||
| MIC90 | |||||||||||
| Overall (88) | Range | <0.03–2 | 0.06–>16 | 0.25–16 | <0.03–4 | <0.03–>16 | <0.03–4 | 0.06–8 | <0.03–1 | 0.03–1 | |
| GM | 0.64 | 1.37 | 1.68 | 0.43 | 0.43 | 0.09 | 1.91 | 0.19 | 0.12 | ||
| MIC90 | 2.00 | 4.00 | 4.00 | 0.50 | 1.00 | 1.00 | 8.00 | 0.50 | 0.25 | ||
| Toxicocladosporium | T. irritans (2) | Range | 0.5–1 | 0.25–2 | 0.25 | 0.25–1 | 0.5 | <0.03–0.06 | 0.125–2 | 0.06–0.25 | 0.06–0.5 |
| GM | 0.71 | 0.71 | 0.25 | 0.50 | 0.50 | 0.03 | 0.50 | 0.12 | 0.17 | ||
| MIC90 | |||||||||||
| Toxicocladosporium sp. (1) | Range | 0.5 | 0.125 | 0.25 | 0.125 | 0.125 | <0.03 | 1 | 0.125 | 0.06 | |
| GM | |||||||||||
| MIC90 | |||||||||||
| Overall (3) | Range | 0.5–1 | 0.125–2 | 0.25 | 0.125–1 | 0.125–0.5 | <0.03–0.06 | 0.125–2 | 0.06–0.25 | 0.06–0.5 | |
| GM | 0.63 | 0.40 | 0.25 | 0.31 | 0.31 | 0.02 | 0.63 | 0.12 | 0.12 | ||
| MIC90 | |||||||||||
| Penidiella | Penidiella sp. (1) | Range | 2 | 0.06 | 0.125 | 0.06 | >0.03 | >0.03 | 0.25 | 0.25 | 0.25 |
| GM | |||||||||||
| MIC90 | |||||||||||
a
GMs and MIC90s are shown only for species with ≥5 isolates. GM, geometric mean.
b
AMB, amphotericin B; 5FC, flucytosine; VRC, voriconazole; PSC, posaconazole; ITC, itraconazole; CFG, caspofungin; AFG, anidulafungin; MFG, micafungin; TRB, terbinafine.
c
These columns include MEC data.