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. 2015 Aug 18;53(9):2877–2888. doi: 10.1128/JCM.01357-15

TABLE 2.

Distribution of H. pylori virulence markers and antimicrobial susceptibility over multilocus sequence types and geographic origins of H. pylori isolates

Type or origin (no.) of isolates % of isolates positive for virulence factor:
 % of isolates antibiotic resistanta
cag vacA s1 babA2 dupA iceA2 PZ1b PZ2b jhp918 Clarc Mtzr Fqr Tetrd
Multilocus sequence types:
    hpAfrica1 (171) 85 87 75 32 71 80 45 92 1/0 57 4 18
    hpAfrica2 (32) 0 0 28 91 6 66 50 72 2/0 41 0 3
    hpAsia2 (17) 94 59 100 100 47 65 35 24 0/94 59 12 0
    hpEurope (98) 61 67 63 44 57 62 61 51 9/11 45 6 1
    hspAmerind (11) 73 91 73 100 64 0 18 64 0/100 9 9 0
    hspEasia (47) 96 98 91 60 28 40 34 38 11/81 34 11 0
Geographic origins:e
    Africa (158) 57 60 60 77 58 69 47 88 3/1 58 4 13
    North America (94) 72 84 80 74 68 84 50 67 5/13 36 3 11
    South America (41) 88 98 78 63 56 49 44 63 7/22 66 10 2
    Europe (19) 89 89 36 26 42 53 68 32 0/16 16 0 0
    East Asia (54) 100 98 91 52 31 44 39 39 11/80 44 11 0
    Other (11)e 91 100 91 27 45 64 27 55 0/64 36 18 0
a

Clar, clarithromycin resistance; Mtzr, metronidazole resistance; Fqr, fluoroquinolone resistance; Tetr, tetracycline resistance.

b

The presence of PZ1 and PZ2 was determined as described in reference 36.

c

The first value is percent resistance based on A2142G, A2142C, and A2143G mutations, and the second value possible low-level resistance based on the T2182C mutation (52, 60).

d

Tetr is represented by single and double AGA926 mutations and represents only low levels of tetracycline resistance.

e

Geographic origin is based on information included in GenBank data files. The category “other” includes Russia (n = 2), India (n = 5), and Australia (n = 4).