TABLE 9.
Performance of GenoTypeMTBDRsl v2.0 assay for detection of XDR-TB measured against phenotypic DST on 228 clinical isolates and 231 clinical specimensa
| XDR-TB detection | Phenotypic DST result |
|
|---|---|---|
| % or ratio | 95% CI | |
| Clinical isolates | ||
| Sensitivity | 80.4 | 66.8–89.4 |
| Specificity | 95.6 | 91.6–97.8 |
| PPV | 82.2 | 68.7–90.7 |
| NPV | 95.1 | 90.9–97.4 |
| Positive likelihood ratio | 18.3 | 14.1–23.7 |
| Negative likelihood ratio | 0.2 | 0.2–0.3 |
| Diagnostic accuracy | 92.5 | 88.4–95.3 |
| Clinical specimens | ||
| Sensitivity | 81.8 | 61.5–92.7 |
| Specificity | 98.1 | 95.2–99.3 |
| PPV | 81.8 | 61.5–92.7 |
| NPV | 98.1 | 95.2–99.2 |
| Positive likelihood ratio | 42.8 | 25.6–71.5 |
| Negative likelihood ratio | 0.2 | 0.1–0.3 |
| Diagnostic accuracy | 96.5 | 93.3–98.2 |
a
CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.