Table 4.
Sensitivity and specificity results of IP-10-based tests, QFT-IT, and TST evaluated in children with a diagnosis of “active TB” versus “respiratory diseases.”
| Test | Cut-off | Sensitivity % |
Sensitivity % excluding indeterminate results of the QFT |
Specificity % |
Specificity % excluding indeterminate results of the QFT |
|
|---|---|---|---|---|---|---|
| HIV status | ||||||
| HIV-uninfected | IP-10 blood (pg/mL) | 209.1 | 79 | NA | 53 | NA |
| IP-10 urine (mg/g) | 0.0000032 | 53 | NA | 66 | NA | |
| QFT-IT | 53 | 56 | 83 | 88 | ||
| TST | 61 | NA | 82 | NA | ||
|
| ||||||
| HIV-infected | IP-10 blood (pg/mL) | 209.1 | 100 | NA | 17 | NA |
| IP-10 urine (mg/g) | 0.0000032 | 54 | NA | 61 | NA | |
| QFT-IT | 17 | 17 | 82 | 100 | ||
| TST | 23 | NA | 94 | NA | ||
TB: tuberculosis; HIV: Human Immunodeficiency Virus; QFT-IT: QuantiFERON TB-Gold In-Tube; TST: tuberculin skin test; IP-10: interferon-γ-inducible protein 10.