Table 3.
Weight of Evidence for Newly Identified Periodontal Pathogens in the Etiology of Periodontitis
| Taxa | Studies, n |
|---|---|
| Evidence: Moderate | |
| Phylum Bacteroidetes | |
| Bacteroidales [G-2] sp. oral taxon 274 HOT 274 (–)a [Bacteroidetes clone AU126 / Phylotype AU126 / Bacteroidales OT 274] | 3 |
| Porphyromonas endodontalis HOT 273 (–)a | 4 |
| Phylum Firmicutes | |
| Eubacterium [XI] [G-5] saphenum HOT 759 (+)a [Eubacterium saphenum] | 5 |
| Mogibacterium timidum HOT 042 (+)a | 3 |
| Peptostreptococcus stomatis HOT 112 (+)a [Peptostreptococcus sp. oral clone CK035] | 3 |
| Filifactor alocis HOT 539 (+)a | 5 |
| Anaeroglobus geminatus HOT 121 (–)a [Megasphaera oral clone BB166] | 3 |
| Selenomonas sputigena HOT 151 (–)a | 5 |
| Enterococcus faecalis HOT 604 (+)b | 4 |
| Phylum Proteobacteria | |
| Desulfobulbus sp. oral taxon 041 HOT 041 [Desulfobulbus sp. oral clone R004 / Desulfobulbos sp. OT 041 / Desulfobulbus R004]c | 3 |
| Phylum Spirochaetes | |
| Treponema lecithinolyticum HOT 653 (–)a | 4 |
| Treponema medium HOT 667 (–)a | 5 |
| Treponema vincentii HOT 029 (–)a | 3 |
| Phylum Synergistetes | |
| Fretibacterium sp. oral taxon 360 HOT 360 [Deferribacteres clone BH017 / Synergistes oral taxon 360 / Synergistetes OTU 7P22 / Synergistes [G-3] sp. OT 360]c | 4 |
| Fretibacterium sp. oral taxon 362 HOT 362 [Deferribacteres clone D084 / Synergistetes [G-3] sp. OT 362 / Synergistetes OTU 2P9 / Synergistetes OTU 6P18]c | 3 |
| Fretibacterium fastidiuosum HOT 363 (–)a [Deferribacteres sp. oral clone W090 / Synergistetes [G-3] sp. OT 363 / Synergistetes OT 4P12] | 3 |
| Phylum Candidatus saccharibacteria (Syn. Candidate division TM7) | 3 |
| TM7 [G-5] sp. oral taxon 356 HOT 356 [TM7 clone I025]c | 3 |
| Archaea domain | 3 |
| Evidence: Some | |
| Phylum Bacteroidetes | |
| Prevotella denticola HOT 291 (–)a | 2 |
| Alloprevotella tannerae HOT 466 (–)a [Prevotella tannerae] | 2 |
| Phylum Firmicutes | |
| Selenomonas genus (–)a | 2 |
| Johnsonella sp. oral taxon 166 HOT 166 [Johnsonella CK051]c | 2 |
| Eubacterium [X1] [G-3] brachy HOT 557 (+)a [Eubacterium brachy ] | 2 |
| Peptostreptococcaceae [XIII] [G-1] sp. oral taxon 113 HOT 113 [Peptoniphilus oral taxon 113]c | 2 |
| Lachnospiraceae [G-8] sp. oral taxon 500 HOT 500 [Lachnospiraceae JM048]c | 2 |
| Dialister pneumosintes HOT 736 (–)a | 2 |
| Phylum Proteobacteria | |
| Acinetobacter baumannii HOT 554 (–)a | 2 |
| Escherichia coli HOT 574 (–)b | 2 |
| Phylum Spirochaetes | |
| Treponema phylogroup II (–)a | 2 |
| Phylum Synergistetes | |
| Fretibacterium sp. oral taxon 359 HOT 359 [Deferribacteres sp. Oral Clone BH007 / Synergistetes OTU 7P1]c | 2 |
| Phylum Candidatus saccharibacteria (Syn. Candidate division TM7) | |
| TM7 [G-1] sp. oral taxon 346 HOT 346 [TM7 401H12]c | 2 |
| TM7 [G-1] sp. oral taxon 349 HOT 349c | 2 |
| Candidate division Sulphur River 1 (Candidate division SR1) | |
| SR1 [G-1] sp. oral taxon 345 HOT 345 [OP11 clone X112 / Phylotype X112]c | 2 |
Species, phylothype, phylum, or domain found in statistically significantly higher levels and/or prevalence and/or proportion and/or abundance in periodontitis than in periodontal health in 3, 4, or 5 studies (moderate evidence) or in 2 studies (some evidence). [Brackets] indicate other nomenclatures for the species or phylotype used among the different studies.
+
, Gram positive; –, Gram negative.
a
Anaerobic.
b
Facultative anaerobic.
c
Species not-yet-cultivable.