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. 2014 Sep;93(9):911–917. doi: 10.1177/0022034514544507

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Figure 3. — The effect of pretreatment with transient receptor potential channel antagonists on changes in [Ca²⁺]_i in cultured human odontoblast-like cells induced by TRPV4 and TRPA1 agonists. (a) The TRPV4 antagonist HC067047 (10nM-2µM) caused a concentration-dependent reduction in the increase in intracellular Ca²⁺ concentration caused by 200nM GSK1016790A. The TRPA1 antagonist HC030031 (0.1-100µM) caused a concentration-dependent reduction in the increase in intracellular Ca²⁺ concentration caused by (b) 200µM AITC and (c) 200µM CA. The TRPA1 antagonist AP18 (0.1-100µM) caused a concentration-dependent reduction in the increase in intracellular Ca²⁺ concentration caused by (d) 200µM allyl isothiocyanate (AITC) and (e) 200µM cinnamaldehyde (CA). n = 4 triplicate measurements.