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. 2015 Jul;10(7):1076–1081. doi: 10.4103/1673-5374.160097

Figure 2.

Figure 2

Effects of progesterone (PROG) on blood-brain barrier (BBB) leakage after permanent middle cerebral artery occlusion.

(A) Evans blue dye penetrates the ischemic brain tissue as early as 6 hours and persists up to 48 hours. More leakage occurs in the ischemic core than in the ischemic Pen. **P < 0.01, vs. corresponding Contra; †††P < 0.001, vs. corresponding Pen and Contra; &P < 0.05, vs. 6 and 24 hours in the Pen. (B) PROG reduces BBB leakage 48 hours, but not 24 hours, after stroke in the Pen. PROG does not affect BBB leakage in the ischemic core (n = 6 per time point). *P < 0.05, vs. corresponding Contra; #P < 0.05, vs. V-48 hours Pen. V: Vehicle; P: progesterone-treated; Pen: penumbra; Contra: contralateral hemisphere.