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. 2015 Jul;10(7):1076–1081. doi: 10.4103/1673-5374.160097

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Copyright: © Neural Regeneration Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Progesterone (PROG) inhibited the down-regulation of zonula occludens-1 (ZO-1) mRNA and protein after permanent middle cerebral artery occlusion (pMCAO).

(A) High expression of ZO-1 mRNA was observed in the control group, and ischemia induced littled transcription of ZO-1 mRNA. ZO-1 mRNA was more highly expressed in the PROG group than in the ischemia and vehicle groups, and was less than that that of the control group. There was a marked up-regulation of ZO-1 mRNA compared with the ischemia and vehicle groups (n = 6 per group; *P < 0.05). (B) PROG inhibited the down-regulation of the expression of ZO-1 protein after pMCAO. There was a marked up-regulation of ZO-1 protein in the PROG group compared with the ischemia and vehicle groups (n = 6 per group; *P < 0.05).