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. 2015 Jul;10(7):1113–1119. doi: 10.4103/1673-5374.160106

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Copyright: © Neural Regeneration Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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PC12 cell apoptosis after co-treatment of quercetin (Qc) and MPP⁺ or 6-OHDA (fluorescence activated cell sorter (FACS) analysis).

(A) A representative result of FACS. AV: Annexin V immunoreactive cells; PI: propidium iodide immunoreactive cells; AV + PI: annexin V and propidium iodide immunoreactive cells. (B) Early apoptotic fraction increases at higher concentration of quercetin (Qc) (C, D). In the baseline (Qc = 0 μM), apoptosis is more dominant with 1-methyl-4-phenylpyridinium 1-methyl-4-phenylpyridinium (MPP⁺) treatment than 6-hydroxydopamine (6-OHDA) (chi-square test, *P < 0.05). Co-treatment of Qc and MPP⁺ decreases apoptotic fraction at 100 μM of Qc (analysis of variance, #P < 0.05). In the cells treated with 6-OHDA, co-treatment of Qc has no effect. Each experiment was performed in triplicate.