Table 3. Frequently selected pathway markers for prostate cancer prognosis.
| Pathway name | Frequency | Topologically important differential genes and metabolites |
|---|---|---|
| Benign–PCA | ||
| Porphyrin and chlorophyll metabolism | 1030/1500 | GUSB, FTH1, HMBS, ALAD, Glycinea |
| Purine metabolism | 416/1500 | POLR2H, PAICS, POLR3GL, NUDT9, NME1, AK2, NT5C, NME2, PAPSS1, POLR1A, PDE4A, GUCY1A3, ENTPD5, ENTPD3, PGM1, ADCY2, NUDT5, ITPA, POLR1E, Glycine |
| Pentose and glucuronate interconversions | 62/1500 | ALDH2, GUSB, AKR1B1 |
| Drug metabolism - other enzymes | 49/1500 | UCK2, GUSB, TK1, ITPA |
| One carbon pool by folate | 40/1500 | AMT, MTHFD2, SHMT2 |
| PCA–Mets | ||
| Steroid hormone biosynthesis | 701/1500 | HSD17B6, SRD5A2, CYP1A1, Cholesterol, Dehydroepiandrosterone sulfate |
| Purine metabolism | 222/1500 | NT5C2, PDE8B, POLD1, NME5, PGM1, PNP, ADK, ADSL, POLR2J2, PKM2, NT5M, NT5C1A, ADCY2, ALLC, PDE6A, Adenosine, Inosine, Urea, Urate, Guanosine |
| Tryptophan metabolism | 131/1500 | MAOB, ALDH7A1, ACAT1, ALDH3A2, ALDH1B1, CCBL1, CYP1A1, ALDH2, Tryptophan |
| Arginine and proline metabolism | 105/1500 | LAP3, MAOB, ALDH7A1, ARG2, ALDH3A2, ODC1, ALDH1B1, SMS, GOT2, ALDH2, PYCRL, Putrescine, L-Proline, L-Aspartate, Sarcosine, Urea, Spermidine, Spermine, 4-Acetamidobutanoate |
| Arachidonic acid metabolism | 89/1500 | PLA2G4A, HPGDS, PLA2G2D |
| Histidine metabolism | 68/1500 | MAOB, ALDH7A1, ALDH3A2, ALDH1B1, HNMT, HDC, ALDH2, L-Aspartate |
| Glycine, serine and threonine metabolism | 53/1500 | AOC3, MAOB, ALDH7A1, SHMT2, SRR, DLD, L-Aspartate, Sarcosine, O-Phospho-L-serine, L-Serine, Tryptophan |
| Drug metabolism - other enzymes | 45/1500 | DPYD, TK1, TYMP |
aMetabolites are shown in italics.