Figure 1.

(a–c) Show negative stained transmission electron micrographs depicting the self-assembly of Aβ_1–42 at pH 7.4, 50 μM. (a) Shows small spherical oligomers that are visible immediately after preparation of Aβ_1-42 peptide (Soura et al⁵⁰). These assemble further by 24 h to form (b) elongated protofibrils, and finally (c) amyloid fibrils after 48 h incubation. d Shows a structural model of an amyloid fibril composed of cross-β structure and showing a slow twisted architecture. Generation of the model is described in Morris et al.¹⁰¹