Figure 5. Examples of genes with known functional role in CD8+ T cells that display inverse correlation between gene expression and DNA methylation.
(A) LGALS1, (B) IFNG, (C) CCR7 and (D) SATB1 gene. Each panel is composed of three sections. The top sections display the different transcripts of the gene, marked according to the expression level fold change between younger and older individuals. The middle sections show the associated CpG sites that are differentially methylated. The scatter plots in the bottom sections illustrate the correspondence between expression and methylation levels for each site separately. The scatter plots are displayed in the same order as the sites in the middle section; the red and blue dots display levels detected in the younger and older individuals, respectively.