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. 2015 Aug 19;5:13183. doi: 10.1038/srep13183

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(a) FRET stabilization potential of carbazole derivatives 5 and BTC a-g (1.0 μM) upon binding to c-MYC, c-KIT1 and c-KIT2 quadruplex, T_m (°C) for c-MYC = (70.9 ± 1.2), c-KIT1 = (53.0 ± 1.7), c-KIT2 = (70.0 ± 1.4), ds DNA = (61.2 ± 2.1). (b) FRET competition assay of BTC f (1.0 μM) for G-quadruplexes (200 nM) in the presence of duplex DNA (200 nM, 1.0 μM, 2.0 μM and 20.0 μM). (c) Thermal shift profiles for BTC f upon stabilizing to quadruplexes and duplex DNA; buffer: 50 mM potassium cacodylate, pH 7.4.