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. 2015 May 27;98(3):385–393. doi: 10.1189/jlb.2A0814-384R

Figure 1. T Cell-specific, IκB-ζ-deficient mice exhibit disrupted immune homeostasis with age.

Figure 1.

(A) Relative IκB-ζ expression in Nfkbizf/f (Control) and Nfkbizf/f Lck-Cre (cKO) mice. Data shown are the means ± sd of duplicate samples and are representative of 2 independent experiments. (B) Representative appearance (upper) and macroscopic view (lower) of 6- to 18-month-old Nfkbizf/f (Control) and Nfkbizf/f Lck-Cre (cKO) mice. (C) Absolute numbers of lymphocytes in the spleen and LNs of 6- to 18-month-old Nfkbizflox/flox (Control) and Nfkbizflox/floxLck-Cre (cKO) mice. (D) Histopathology of the liver. H&E staining or CD3 immunostaining of tissue sections from 6- to 18-month-old mice. (E and F) Serum concentrations of ANA (E) and anti-dsDNA (F) in Nfkbizflox/flox (Control) and Nfkbizflox/floxLck-Cre (cKO) mice. Original scale bars, 100 µm. Original magnification, 20× (D). *P < 0.05.