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. 2015 May 27;98(3):385–393. doi: 10.1189/jlb.2A0814-384R

Figure 5. T Cell-specific, IκB-ζ-deficient mice have higher sensitivity to DSS-induced colitis.

Figure 5.

(A) Relative weight loss of Nfkbizf/f (Control; n = 7) and Nfkbizf/f Lck-Cre (cKO; n = 5) mice after 2% DSS treatment. The horizontal bars represent the means ± sem. (B) Histopathology of the colon. H&E staining of tissue sections at 9 days after DSS treatment. Data are representative of 3 independent experiments. (C and D) Percentage of FOXP3+ Tregs (C) or IFN-γ production in CD4+ T cells (D) in colonic lamina propria from Nfkbizf/f (Control) and Nfkbizf/f Lck-Cre mice at 9 days after 2% DSS treatment (data for 2 mice pooled together for analysis). Original scale bars, 100 µm. Original magnification, 10× (B). **P < 0.01.