Figure 3.

Normal basal gonadotropin levels but impaired positive feedback induction of LH surges in KissPRKO females. Mean basal serum LH and FSH levels in 12-week-old female (A) and male (B) WT and KissPRKO mice (females in diestrus). C, Mean number of CL in ovaries of 12-week-old WT and KissPRKO females. D and E, Mean serum LH levels and percentage of females displaying an LH surge in 12-week and 8-month-old females exposed to a validated E₂-positive feedback regimen known to elicit LH surge at the evening but not morning time point. *, Significantly different from each other (P < .05); #, nonsignificant trend for genotype difference (P < .10).