Table 3. Determination of the Genetic Effects of IL-10 and IL-6 Polymorphisms on TB and Subgroup Analysis.
| Allele model | Homozygous model | Heterozygous model | Dominant model | Recessive model | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Effect model OR (95% Cl) | p value | Effect model OR (95% Cl) | p value | Effect model OR (95% Cl) | p value | Effect model OR (95% Cl) | p value | Effect model OR (95% Cl) | p value | |
| IL-10-1082G/A | G allele vs. A allele | GG vs. AA | AG vs. AA | GG+AG vs. AA | GG vs. AG+AA | |||||
| Ethnicity | ||||||||||
| Overall | 1.05(0.93,1.19) | 0.423 | 1.15(0.87,1.51) | 0.320 | 1.08(0.90,1.29) | 0.393 | 1.09(0.91,1.31) | 0.335 | 1.09(0.87,1.38) | 0.448 |
| European | 1.34(1.00,1.80) | 0.054 | 1.88(0.93,3.80) | 0.079 | 1.35(0.70,2.63) | 0.369 | 1.49(0.79,2.79) | 0.215 | F1.69(1.19, 2.39) | 0.003 |
| American | F1.10(0.95,1.27) | 0.201 | F1.16(0.81,1.67) | 0.421 | F1.07 (0.88,1.30) | 0.509 | F1.09 (0.90,1,31) | 0.372 | F1.23 (0.90,1.68) | 0.203 |
| Asian | 0.85(0.67,1.09) | 0.209 | 0.69(0.36,1.36) | 0.285 | 0.91(0.66,1.26) | 0.940 | 0.89(0.63,1.25) | 0.494 | 0.67(0.36,1.26) | 0.212 |
| African | 1.12(0.91,1.38) | 0.289 | 1.20(0.81,1.77) | 0.369 | 1.32(0.93,1.87) | 0.126 | 1.31 (0.92,1.88) | 0.131 | F0.97 (0.81,1.17) | 0.761 |
| Sample types | ||||||||||
| PTB | 0.98(0.85,1.12) | 0.726 | 0.93(0.70,1.25) | 0.646 | 0.97(0.81,1.15) | 0.691 | 0.96(0.80,1.15) | 0.651 | 1.01 (0.76,1.34) | 0.958 |
| PTB+EPTB | 1.23(0.94,1.62) | 0.130 | 2.00(1.16,3.45) | 0.013 | 1.53(0.95,2.49) | 0.084 | 1.56(0.97,2.52) | 0.067 | 1.31 (0.89,1.93) | 0.176 |
| IL-10-819C/T | T allele vs. C allele | TT vs. CC | TC vs. CC | TT+TC vs. CC | TT vs. TC+CC | |||||
| Ethnicity | ||||||||||
| Overall | F1.01 (0.95,1.07) | 0.788 | F1.01 (0.89,1.15) | 0.834 | 1.21(1.00,1.46) | 0.056 | 1.14(0.98,1.34) | 0.099 | F0.93 (0.84,1.03) | 0.164 |
| European | F0.92(0.71,1.19) | 0.512 | F0.75 (0.40,1.42) | 0.380 | F0.97 (0.68,1.37) | 0.846 | 0.93(0.67,1.30) | 0.678 | F0.79 (0.43,1.44) | 0.438 |
| American | F1.04 (0.85,1.27) | 0.732 | F1.08(0.71,1.65) | 0.721 | F1.03 (0.76,1.39) | 0.870 | F1.04 (0.78,1.38) | 0.799 | F1.06 (0.72,1.57) | 0.756 |
| Asian | F1.08 (0.95,1.23) | 0.265 | F1.24 (0.92,1.67) | 0.157 | F1.34 (1.02,1.77) | 0.035 | F1.31 (1.01,1.70) | 0.043 | F1.01 (0.84,1.22) | 0.897 |
| African | F0.99 (0.92,1.07) | 0.812 | F0.97 (0.83, 1.13) | 0.691 | 1.34(0.90,2.00) | 0.148 | 1.21 (0.89,1.64) | 0.231 | F0.88 (0.77,1.01) | 0.065 |
| Control source | ||||||||||
| HB | F1.01 (0.93,1.10) | 0.785 | F1.04 (0.87,1.24) | 0.685 | 1.20(0.92,1.55) | 0.175 | 1.13(0.92,1.39) | 0.237 | F0.93 (0.81,1.07) | 0.310 |
| PB | F1.01(0.92,1.09) | 0.919 | F0.99 (0.82,1.19) | 0.908 | 1.26(0.89,1.78) | 0.201 | 1.20(0.88,1.64) | 0.258 | F0.92 (0.79, 0.84) | 0.339 |
| IL-10-592A/C | A allele vs. C allele | AA vs. CC | AC vs. CC | AA+AC vs. CC | AA vs. AC+CC | |||||
| Ethnicity | ||||||||||
| Overall | 1.07(0.95,1.19) | 0.270 | 1.09(0.89,1.33) | 0.401 | F1.01 (0.91, 1.12) | 0.839 | 1.06(0.91,1.22) | 0.474 | 1.09(0.93,1.29) | 0.291 |
| European | F0.84 (0.65,1.09) | 0.181 | F0.64 (0.35,1.18) | 0.153 | F0.90(0.63,1.27) | 0.536 | F0.85 (0.61,1.18) | 0.323 | F0.68 (0.38,1.23) | 0.204 |
| American | 1.01(0.80,1.28) | 0.918 | F0.93 (0.72,1.20) | 0.595 | 0.91(0.64,1.31) | 0.623 | 0.97(0.67,1.39) | 0.859 | F1.07 (0.86,1.34) | 0.545 |
| Asian | F1.26 (1.08,1.45) | 0.002 | F1.50 (1.07, 2.12) | 0.020 | F1.21 (0.88,1.67) | 0.250 | F1.35 (0.99,1.83) | 0.058 | F1.33 (1.10,1.62) | 0.004 |
| African | 1.12(0.91,1.37) | 0.290 | 1.12(0.79,1.58) | 0.528 | F1.11(0.97,1.27) | 0.144 | F1.09 (0.96,1.24) | 0.175 | 1.08(0.77,1.52) | 0.654 |
| Control source | ||||||||||
| HB | 1.08(0.94,1.24) | 0.254 | 1.14(0.90,1.45) | 0.289 | F0.95(0.84,1.08) | 0.429 | 1.07(0.89,1.29) | 0.464 | 1.15(0.97,1.37) | 0.111 |
| PB | 1.00(0.89,1.1 1) | 0.933 | 0.94(0.75,1.19) | 0.607 | F1.13(0.95,1.34) | 0.154 | 1.08(0.91,1.22) | 0.359 | 0.87(0.71,1.07) | 0.194 |
| IL-6-174G/C | C allele vs. G allele | CC vs. GG | CG vs. GG | CC+CG vs. GG | CC vs. CG+GG | |||||
| Overall | F0.77 (0.64, 0.91) | 0.003 | F0.67 (0.43,1.05) | 0.078 | F0.72(0.57, 0.90) | 0.005 | F0.71 (0.57, 0.88) | 0.002 | F0.77 (0.50,1.19) | 0.243 |
| European | F0.92 (0.67,1.26) | 0.594 | 0.73(0.22,2.43) | 0.610 | F1.00(0.64,1.57) | 0.987 | F0.94 (0.62,1.42) | 0.773 | 0.72(0.20,2.59) | 0.615 |
| Asian | F0.71 (0.54,0.93) | 0.013 | F0.69 (0.32,1.48) | 0.343 | F0.61 (0.44,0.85) | 0.004 | F0.63 (0.46, 0.86) | 0.004 | F0.93 (0.44,1.97) | 0.855 |
TB, tuberculosis; PTB, pulmonary tuberculosis; EPTB, extra-pulmonary tuberculosis; PB, population-based controls; HB, hospital-based controls; R, random effect model; F, fixed effect model; IL-10, interleukin 10; IL-6, interleukin 6; CI, confidence interval; OR, odds ratio.