Table 5. Multivariate Meta-Regression Analyses of Potential Source of Heterogeneity.
| Heterogeneity factors | Coefficient | SE | t | p value | 95% CI | |
|---|---|---|---|---|---|---|
| LL | UL | |||||
| Sample types | ||||||
| IL-10-1082G/A (AM, HoM, HeM, DM, RM) | 0.234, 0.924, 0.407, 0.433, 0.457 | 0.183, 0.361, 0.278, 0.279, 0.289 | 1.28, 2.56, 1.46, 1.55, 1.58 | 0.215, 0.019, 0.158, 0.136, 0.130 | -0.146, 0.170, -0.171, -0.148, -0.146 | 0.614, 1.679, 0.985, 1.014, 1.061 |
| IL-10-819C/T (HeM, DM) | -0.119, -0.071 | 0.345, 0.285 | -0.35, -0.25 | 0.737, 0.808 | -0.887, -0.706 | 0.649, 0.564 |
| IL-10-592A/C (AM, HoM, DM, RM) | -0.091, -0.104, -0.162, -0.055 | 0.158, 0.316, 0.203, 0.235 | -0.57, -0.33, -0.80, -0.23 | 0.577, 0.748, 0.440, 0.819 | -0.438, -0.800, -0.609, -0.572 | 0.256, 0.592, 0.284, 0.462 |
| Ethnicity | ||||||
| IL-10-1082G/A (AM, HoM, HeM, DM, RM) | -0.082, -0.118, 0.014, -0.031, -0.223 | 0.077, 0.141, 0.124, 0.124, 0.108 | -1.07, -0.83, 0.11, -0.25, -2.06 | 0.298, 0.415, 0.910, 0.804, 0.052 | -0.241, -0.413, -0.244, -0.290, -0.448 | 0.077, 0.177, 0.272, 0.227, 0.002 |
| IL-10-819C/T (HeM, DM) | 0.116, 0.082 | 0.141, 0.115 | 0.82, 0.71 | 0.433, 0.493 | -0.120, -0.175 | 0.431, 0.339 |
| IL-10-592A/C (AM, HoM, DM, RM) | 0.067, 0.106, 0.084, 0.062 | 0.067, 0.137, 0.082, 0.110 | 1.00, 0.78, 1.02, 0.57 | 0.339, 0.453, 0.329, 0.583 | -0.081, -0.195, -0.097, -0.179 | 0.215, 0,407, 0.264, 0.304 |
| Control source | ||||||
| IL-10-1082G/A (AM, HoM, HeM, DM, RM) | 0.093, 0.528, -0.137, -0.057, 0.545 | 0.207, 0.366, 0.308, 0.311, 0.295 | 0.45, 1.44, -0.44, -0.18, 1.85 | 0.659, 0.166, 0.661, 0.855, 0.080 | -0.338, -0.239, -0.776, -0.705, -0.070 | 0.524, 1.295, 0.503, 0.590, 1.161 |
| IL-10-819C/T (HeM, DM) | 0.053, 0.051 | 0.363, 0.294 | 0.14, 0.17 | 0.888, 0.867 | -0.757, -0.605 | 0.862, 0.707 |
| IL-10-592A/C (AM, HoM, DM, RM) | -0.157, -0.368, -0.090, -0.395 | 0.191, 0.362, 0.225, 0.265 | -0.82, -1.02, -0.40, -1.49 | 0.429, 0.331, 0.697, 0.165 | -0.577, -1.165, -0.585, -0.978 | 0.263, 0.429, 0.405, 0.189 |
| Genotyping method | ||||||
| IL-10-1082G/A (AM, HoM, HeM, DM, RM) | 0.075, 0.124, 0.051, 0.068, 0.137 | 0.064, 0.121, 0.098, 0.099, 0.095 | 1.17, 1.02, 0.52, 0.69, 1.44 | 0.254, 0.319, 0.606, 0.499, 0.164 | -0.058, -0.129, -0.152, -0.137, -0.061 | 0.209, 0.376, 0.254, 0.273, 0.335 |
| IL-10-819C/T (HeM, DM) | 0.006, 0.022 | 0.131, 0.106 | 0.05, 0.21 | 0.965, 0.840 | -0.285, -0.214 | 0.297, 0.257 |
| IL-10-592A/C (AM, HoM, DM, RM) | 0.015, 0.074, -0.024, 0.090 | 0.060, 0.117, 0.073, 0.089 | 0.24, 0.63, -0.32, 1.01 | 0.813, 0.538, 0.752, 0.336 | -0.118, -0.183, -0.185, -0.107 | 0.147, 0.331, 0.137, 0.286 |
SE, standard error; CI, confidence interval; UL, upper limit; LL, lower limit; AM, allele model; HoM, homozygous model; HeM, heterozygous model; DM, dominant model; RM, recessive model; IL-10, interleukin 10.