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Changes in [Ca2+]i in pancreatic β cells from mice exposed to T1D or control sera. Five of seven T1D sera induced an enhanced increase in [Ca2+]i, when the cells were depolarized with high concentrations of K+ to open the voltage-gated Ca2+ channel, compared with cells that had been exposed to normal serum (n = 29, 28, 32, 47, 21, 27, 31, and 18, respectively), ***, P < 0.001; **, P < 0.01; *, P < 0.05 versus control.
