| Nebivolol is the only vasodilatory β1-selective blocker; the vasodilatory effect is nitric oxide-mediated and activated via β3-agonism. |
| Nebivolol effectively lowers blood pressure either alone or in combination with other antihypertensive drugs. |
| The unique pharmacological profile of nebivolol coupled with clinical evidence suggests potential utility in the treatment of hypertension and heart failure with reduced ejection fraction. |
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