Fig 2.

SOCS1 protein levels were increased in bronchial biopsy specimens from adults with mild-to-moderate AA compared with those seen in NANA adults and correlated with asthma-related clinical outcomes. A, Representative pictures showing epithelial staining of SOCS1 (left panels) and SOCS3 (right panels). Bar = 10-μm scale (×40 objective was used in all pictures). Patients with AA showed significantly more SOCS1, but not SOCS3, staining compared with that seen in NANA subjects. *P < .05, bar represents median. ns, Not significant. B, SOCS1 bronchial biopsy scores positively correlated with the number of positive skin pick test responses (SPTs) and negatively correlated with the dose of histamine causing a 20% reduction in lung function (PC₂₀).