Table 1.

Summary of microRNAs which may play a potential role in PH.

microRNAs	Expression in PH	Research object	Function in PH	Mechanisms	References
MiR-22	reduced	animal	unknow	unknow	25
miR-30	reduced	animal	unknow	unknow	25
let-7f	reduced	animal	unknow	unknow	25
miR-21	reduced	animal and human	unknow	unknow	25
let-7a	reduced	animal	unknow	unknow	25
miR-150	reduced	human	protect	unknow	27
miR-204	reduced	animal and human	protect	target SHP2, inhibit PASMCs proliferation	26
miR-322	increased	animal	unknow	unknow	25
miR-451	increased	animal	unknow	unknow	25
miR-210	increased	animal	impair	Antiapoptotic effect in PASMCs	29
miR-21	increased	animal	impair	Enhanced the proliferation of human PASMCs	31,32
miR-759	increased	human	protect	Decrease the amount of total FGA mRNA via affecting the stability of FGA long isoform (aE) mRNA, which can contribute to CTEPH.	35
miR-17/92, 20a	increased	animal	impair	STAT3-miR-17/92-BMPR2 pathway	37,40
miR-145	incerased	animal and human	impair	Inhibit the BMPR2 function	38,39
miR-143	increased	animal and human	impair	Prevents down-regulation of KLF4 and activation of contractile genes by TGF-β or BMP4	38
miR-17	increased	animal	impair	up-regulation of p21	41
miR-206	decreased	animal	protect	down regulating Notch-3	43
miR-328	decreased	animal and human	protect	Inhibit L-type calcium channel-a1C expression	44
miR-26a	decreased	animal and human	unknow	unknow	28
miR-424	decreased	animal	protect	FGF2 pathways	42
miR-503	decreased	animal	protect	FGF2 pathways	42