Fig. 3.

The nAb response in experimentally infected chimpanzees. Sequential plasma samples from six chronically H77-virus-infected chimpanzees were monitored for viral RNA levels, nAb for pseudotype virus bearing autologous H77 gp (HIV-HCV H77), and anti-E1E2 and anti-HVR reactivity. All plasma samples were tested at a dilution of 1/100. Data are shown as percentage neutralization. The anti-E1E2 and anti-HVR Ab data are represented as a P/N ratio, calculated by dividing the OD value of the test sera by that obtained with a preimmune serum. P/N values >2 were considered positive. All assays were performed in quadruplicate, and the data are representative of two independent experiments.