Table 1. Genotype-independent pattern of neutralization in chronic HCV infection.
| Neutralization of plasma from individuals infected with different HCV genotypes,* %
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Infecting genotype
|
||||||||||||||
| 1a
|
1b
|
2a
|
2b
|
3a
|
4a
|
|||||||||
| Patient 79 | Patient 113 | Patient 58 | Patient 105 | Patient 218 | Patient 513 | Patient 343 | Patient 72 | Patient 357 | Patient 211 | Patient 858 | Patient 321 | Patient 486 | Patient 530 | |
| HIV-HCV H (1a) | 95 | 74 | 92 | 92 | 92 | 93 | 53 | 91 | 90 | 87 | 95 | 86 | – | 97 |
| HIV-HCV H77 (1a) | >99 | >99 | 98 | >99 | >99 | >99 | 85 | >99 | >99 | >99 | >99 | >99 | >99 | >99 |
| HIV-HCV HCJ4 (1b) | 92 | 55 | 88 | 91 | 86 | 94 | 85 | 93 | 95 | 89 | 64 | 78 | 63 | 92 |
| HIV-HCV HCJ6 (2a) | 96 | 94 | 85 | – | 84 | 89 | 81 | 72 | 63 | 77 | 63 | 93 | 76 | 59 |
–, percentage neutralization <50%. Viral genotypes are listed in parentheses.
*
All plasma samples were tested at a dilution of 1/200