Fig. 2.
Suppression of GABAA-current run-down by phosphatase inhibitors. (Lower) Time course of current run-down during repetitive applications of GABA to oocytes injected with TL membranes from patient 3 (see Table 1). Points represent means (±SEM) from nine oocytes (three frogs). Symbols denote different treatments, as indicated. (Upper) Sample currents from the same experiments, as indicated by symbols. Currents were normalized to Imax = -55 ± 7 nA (▪), -72 ± 6 nA (○), and -98 ± 4 nA (•). Note current run-down is reduced by orthovanadate and prevented by okadaic acid.