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. 2015 May 19;80(2):235–241. doi: 10.1111/bcp.12616

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Mean (± SE) change from baseline to SUPER-1 final visit in (A) serum creatinine and (B) estimated glomerular filtration rate (eGFR). *P = 0.032 vs. placebo, least squares mean difference. ^†P = 0.009 and ^‡P = 0.016 vs. placebo, least squares mean difference using analysis of covariance with treatment as the factor and baseline value as the covariate. For the purposes of conversion, 0.02 mg dl^–1 is equivalent to 1.76 µmol l^–1 sCr. , placebo (n = 70); , sildenafil 20 mg three times daily (n = 67); , sildenafil 40 mg three times daily (n = 65); , sildenafil 80 mg three times daily (n = 68)

Inline graphic — Mean (± SE) change from baseline to SUPER-1 final visit in (A) serum creatinine and (B) estimated glomerular filtration rate (eGFR). *P = 0.032 vs. placebo, least squares mean difference. ^†P = 0.009 and ^‡P = 0.016 vs. placebo, least squares mean difference using analysis of covariance with treatment as the factor and baseline value as the covariate. For the purposes of conversion, 0.02 mg dl^–1 is equivalent to 1.76 µmol l^–1 sCr. , placebo (n = 70); , sildenafil 20 mg three times daily (n = 67); , sildenafil 40 mg three times daily (n = 65); , sildenafil 80 mg three times daily (n = 68)