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Kaplan–Meier analysis of (A) time to clinical worsening and (B) time to all-cause mortality by serum creatinine (sCr) status from baseline to week 12; (C) time to clinical worsening and (D) time to all-cause mortality by change in estimated glomerular filtration rate (eGFR) status from baseline to week 12. A–B 
, patients with no change or improvement in sCr; 
, patients with worsening sCr. C–D , patients with no change or improvement in eGFR; , patients with worsening eGFR.
