Table 1.

Amount of required drug exposure to identify potentially drug-induced adverse events

		Weak association (RR≥2)			Moderate association (RR≥4)			Strong association (RR≥6)
Event type	IR per 100 000 PY	Required exposure (PY)	Drugs n	% of Exp	Required exposure (PY)	Drugs n	% of Exp	Required exposure (PY)	Drugs n	% of Exp
Hip fracture	15.3	52 501	6	29.5	8039	42	67.8	3589	81	80.4
Upper GI bleeding	14.4	55 725	5	26.2	8532	39	66.3	3810	79	79.9
Neutropenia	8.1	99 259	2	13.0	15 198	25	56.9	6786	48	70.5
Acute liver injury	4.0	202 733	0	0	31 041	9	37.3	13 860	26	57.8
Pancytopenia	3.7	215 469	0	0	32 991	9	37.3	14 730	25	56.9
Bullous eruption	3.6	224 394	0	0	34 358	9	37.3	15 341	24	56.0
Anaphylactic shock	3.2	248 526	0	0	38 053	8	35.0	16 990	20	52.1
Cardiac valve fibrosis	2.9	275 840	0	0	42 235	8	35.0	18 858	15	46.6
Acute renal failure	1.6	517 050	0	0	79 168	3	17.9	35 348	9	37.3
Acute pancreatitis	1.6	519 664	0	0	79 568	3	17.9	35 527	9	37.3

Drugs (n): Number of drugs at fifth ATC, chemical substance level that have enough PY of exposure to detect a potential signal (total 2170).

% of Exp: Proportion of PYs of exposure of the drugs with enough exposure compared with the total PYs of exposure for all drugs.

IR, incidence rate; PY, person years; RR, relative risk; upper GI bleeding, upper gastrointestinal bleeding