TABLE 2.
Associations between regularity of the activity rhythm and the metabolic syndrome (n=1137)
| Odds Ratio [95% CI] p-value of outcome associated with a 1SD increase in IS |
||||||
|---|---|---|---|---|---|---|
| Model | Covariates | Metabolic Syndrome |
Obesity | Hypertension | Diabetes | Dyslipidemia |
| A | Age, Sex | 0.69 [0.60,0.80] 5.8e-07 |
0.73 [0.63,0.85] 2.5e-05 |
0.78 [0.66,0.91] 2.0e-03 |
0.76 [0.65,0.90] 9.3e-04 |
0.82 [0.72,0.92] 1.2e-03 |
| B | A + Total Activity | 0.75 [0.65,0.88] 3.5e-04 |
0.78 [0.66,0.91] 1.4e-03 |
0.80 [0.68,0.95] 1.1e-02 |
0.83 [0.70,0.98] 3.1e-02 |
0.85 [0.75,0.97] 1.6e-02 |
| C | A + Total Rest | 0.74 [0.63,0.87] 1.8e-04 |
0.79 [0.67,0.92] 3.0e-03 |
0.78 [0.66,0.93] 5.4e-03 |
0.83 [0.70,0.99] 3.5e-02 |
0.86 [0.75,0.98] 2.2e-02 |
| F | A + IV | 0.72 [0.61,0.85] 5e-05 |
0.76 [0.64,0.89] 7.4e-04 |
0.84 [0.71,0.99] 4.7e-02 |
0.81 [0.68,0.97] 1.9e-02 |
0.82 [0.72,0.94] 5.2e-03 |
| G | A + kRA | 0.70 [0.61,0.81] 2.2e-06 |
0.74 [0.64,0.86] 5.4e-05 |
0.79 [0.67,0.93] 4.1e-03 |
0.80 [0.68,0.94] 5.5e-03 |
0.83 [0.74,0.94] 3.9e-03 |
| H | A + BMI | 0.79 [0.67,0.94] 7.6e-03 |
NA | 0.83 [0.70,0.98] 2.6e-02 |
0.81 [0.69,0.96] 1.5e-02 |
0.87 [0.76,0.99] 2.9e-02 |
| I | A + CAD + Stroke + PVD | 0.66 [0.56,0.77] 2.3e-07 |
0.70 [0.60,0.82] 1.0e-05 |
0.82 [0.69,0.97] 2.3e-02 |
0.75 [0.63,0.89] 9.5e-04 |
0.82 [0.72,0.94] 4.2e-03 |
| J | A + Dementia | 0.70 [0.60,0.81] 1.3e-06 |
0.71 [0.62,0.83] 8.3e-06 |
0.78 [0.66,0.91] 1.9e-03 |
0.82 [0.70,0.96] 1.3e-02 |
0.82 [0.73,0.93] 2e-03 |
| K | A + Smoking + Alcohol | 0.70 [0.60,0.81] 1.1e-06 |
0.73 [0.63,0.85] 2.8e-05 |
0.78 [0.67,0.92] 2.8e-03 |
0.79 [0.68,0.93] 3.9e-03 |
0.82 [0.72,0.93] 1.4e-03 |
| L | A + All | 0.70 [0.58,0.84] 1.5e-04 |
0.73 [0.60,0.88] 8.9e-04 |
0.80 [0.66,0.98] 3.2e-02 |
0.84 [0.69,1.03] 9.3e-02 |
0.85 [0.73,0.99] 3.6e-02 |
Abbreviations: OR Odds Ratio. CI confidence interval. SD standard deviation. IS interdaily stability, as calculated in the text. BMI body mass index. CAD coronary artery disease. PVD peripheral vascular disease. IV intradaily variability, as calculated in the text. kRA sleep fragmentation, as calculated in the text. Alcohol consumption measured in grams per week. Obesity, hypertension, diabetes, and dyslipidemia as defined in the text. Metabolic syndrome defined as 3 or more of obesity, hypertension, diabetes, or dyslipidemia.